Study/Substudy cohorts of interest: Cross-sectional Long, ARV Long. Acute and Early HIV Infection Long. Imaging Long. Metabolic Complications Long. Peripheral Neuropathy Long. Viral Genetics   

Year of enrollment into cross-sectional cohort: Enrolled 2003 - 2004 Enrolled 2005 - 2006 Enrolled 2007 - 2008 Enrolled 2009 - 2010   

Number of visits in CHARTER study: 1 - 5 visits in CHARTER 6 - 10 visits in CHARTER 11 - 15 visits in CHARTER 16 - 20 visits in CHARTER   

Number of years enrolled in longtitutional CHARTER substudy: 1 year or less More than 1 to 3 or fewer years More than 3 to 6 or fewer years More than 6 to 9 or fewer years More than 9 to 12 or fewer years   

Evidence for hypertension : Evidence No evidence Not assessed Missing   

Evidence for diabetes : Evidence No evidence Not assessed Missing   

Evidence for hyperlipidemia : Evidence No evidence Not assessed Missing   

Evidence for viral hepatitis : Evidence No evidence Not assessed Missing   

Evidence for liver disease: Evidence No evidence Not assessed Missing   

Evidence for renal disease: Evidence No evidence Not assessed Missing   

Evidence for COPD: Evidence No evidence Not assessed Missing   

Evidence for cerebrovascular disease: Evidence No evidence Not assessed Missing   

Evidence for non-AIDS defining cancer: Evidence No evidence Not assessed Missing   

Evidence for lipodystrophy: Evidence No evidence Not assessed Missing   

Evidence for tobacco use: Evidence No evidence   

Diagnosis of CNS Lymphoma: Negative Positive Not Assessed Unknown   

Diagnosis of Toxoplasmosis of Brain: Negative Positive Not Assessed   

Diagnosis of Progressive Multifocal Leukoencephalopathy (PML): Negative Positive Not Assessed   

Diagnosis of Extrapulmonary Cryptococcosis: Negative Positive Not Assessed   

Diagnosis of Disseminated or Extrapulmonary Histoplasmosis: Negative Positive Not Assessed   

Diagnosis of Disseminated or Extrapulmonary Coccidiodomyccosis: Negative Not Assessed   

Current ARV regimen classification:   ARV Naive No Current ARVs Non-HAART HAART Not assessed Missing   

Beck Depression Inventory Administration: Data available Data not available   

CIDI Diagnosis: No diagnoses or substance use disorder Current diagnosis or substance use disorder Lifetime diagnosis or substance use disorder Not assessed   

Current diagnosis of major depressive disorder: YES NO Not assessed   

Lifetime diagnosis of major depressive disorder: YES NO Not assessed   

Current diagnosis of persistent depressive disorder: YES NO Not assessed   

Lifetime diagnosis of persistent depressive disorder: YES NO Not assessed   

Current alcohol abuse/dependence: YES NO Not assessed   

Lifetime alcohol abuse/dependence: YES NO Not assessed   

Current cannabis abuse/dependence: YES NO Not assessed   

Lifetime cannabis abuse/dependence: YES NO Not assessed   

Current cocaine abuse/dependence: YES NO Not assessed   

Lifetime cocaine abuse/dependence: YES NO Not assessed   

Current hallucinogen abuse/dependence: YES NO Not assessed   

Lifetime hallucinogen abuse/dependence: YES NO Not assessed   

Current opiate abuse/dependence: YES NO Not assessed   

Lifetime opiate abuse/dependence: YES NO Not assessed   

Current sedative abuse/dependence: YES NO Not assessed   

Lifetime sedative abuse/dependence: YES NO Not assessed   

Current amphetamine abuse/dependence: YES NO Not assessed   

Lifetime amphetamine abuse/dependence: YES NO Not assessed   

Current other drug abuse/dependence: YES NO Not assessed   

Lifetime other drug abuse/dependence: YES NO Not assessed   

Availability of cerebrospinal fluid: No sample available Sample available   

Availability of CSF pellets: No sample available Sample available   

Availability of DNA: No sample available Sample available   

Availablility of PAXgene blood DNA tubes: No sample available Sample available   

Availability of PAXgene blood RNA tubes: No sample available Sample available   

Availability of peripheral blood mononuclear cells: No sample available Sample available   

Availability of blood plasma: No sample available Sample available   

Availablility of blood serum: No sample available Sample available   

Availability of whole blood: No sample available Sample available   

Log(base 10) Plasma Viral Load Range (IU/mL) Range: Less than or equal to 1.699 1.700 - 2.602 2.603 - 4.052 Greater than 4.052 Missing Not Assessed   

Absolute CD4 Concentration (cells/uL) Range: 50 or fewer cells 51 - 199 cells 200 - 499 cells 500 or more cells Missing Not Assessed   

Nadir CD4 value: 50 cells or less 51 - 200 cells 201+ cells Missing Not Assessed   

Vital Signs Data Available: Data available Data not available   

Urine Toxicology Screening Results From Day of Testing: Negative urine toxicology Positive urine toxicology Missing Not Assessed   

SNP Data Availability Flag: Data available Data not available   

Current Abstract and Executive Functioning domain impairment: Impaired Not impaired Not assessed   

Current Speed of Information Processing domain impairment: Impaired Not impaired Not assessed   

Current Attention and Working Memory domain impairment: Impaired Not impaired Not assessed   

Current Learning domain impairment: Impaired Not impaired Not assessed   

Current Memory domain impairment: Impaired Not impaired Not assessed   

Current Verbal Fluency domain impairment: Impaired Not impaired Not assessed   

Current Motor domain impairment: Impaired Not impaired Not assessed   

Current Average Global impairment: Impaired Not impaired Not assessed   

Fluid assayed: CSF Plasma Serum   

Biomarker gene name of interest:   

The biomarker data tool uses the HUGO Gene names to identify biomarkers of interest. For more information on the index or to identify the gene symbol relevant to your soluble biomarker of interest, please visit the HUGO Gene Index

Severity of distal sensory polyneuropathy symptoms (independent of DSPN diagnosis) No neuropathy Mild symptoms Moderate symptoms Severe sypmtoms Undetermined Not assessed   

Diagnosis of distal sensory polyneuropathy No DSPN dx Positive DSPN dx Undetermined Not assessed   

Etiology of distal sensory polyneuropathy HIV-associated DSPN Nucleoside-associated DSPN Combined HIV/nucleoside-associated DSPN DSPN - other cause Undetermined Not assessed   

Intraepidermal nerve fiber density data availability Data not available IENFD data available